Pollution in aquatic environment is one of the major environmental threats in the world and pesticides are among the leading polluting agents that affect aquatic organisms. This study has investigated the behavioural effect and haematological profile of chronic concentrations of sharpshooter (Profenofos 40% and Cypermethrin) on Clarias gariepinus over 28 days of exposure. Sub-adult C. gariepinus (150-200g and 25-30cm) were exposed to 0.00ppm, 0.12ppm, 0.24ppm, 0.48ppm, 0.96ppm concentrations of sharpshooter for 28 days. Blood samples were collected at day 7, 14, 21 and 28 and analyzed. Descriptive statistics and one-way ANOVA was used to analyze data. Overt distress behavioural responses like erratic movement, frequent surfacing, copious mucus secretion and grouping together were observed among the treatment groups. Significant changes (p< 0.05) were induced on haematological parameters of C. gariepinus by Sharpshooter (Profenofos 40% and Cypermethrin). We observed that changes in behaviour and haematological profile were concentration and time-dependent. Our findings suggest that chronic exposure of Clarias gariepinus to sharpshooter can lead to abnormal behaviour and significant alterations in the haematological profile (WBC, LYMP, RBC, HGB, MCH, MCHC, PLT, HCT, MCV and MPV) which in turn can lead to; compromised immunity, poor nutrient circulation, slow growth and threat to survival of Clarias gariepinus.   Caution and concrete policies should be put in place to ensure safety of the environment and aquatic organisms.